1. 신주의 재원 : 주식발행 초과금

2. 신주의 발행가액 : 1주당 500원(액면가 금500원)

3. 신주의 종류와 수 : 보통주식 : 257,570주

4. 총 발행금액 : 금128,785,000원

5. 신주의 배정기준일 : 2023. 03. 31.

6. 신주의 배정방법 및 단수주 처리 : 2023. 03. 31. 현재 주주명부에 등재된 주주에게 1주당 0.392주의 비율로 신주를 배정함

2023년 3월 15일

주식회사 에이아이바이오틱스

경상남도 창원시 마산회원구 봉암북7길 21,

5동 404호(봉암동, 경남지능형흠산업화센터)

대표이사 마상배 (직인생략)

A domestic bio company has developed a specimen preprocessing technology that helps miniaturize large diagnostic testing equipment. It is expected to help open the market for popular point-of-care diagnostic devices (POCT) as it can produce highly accurate test results without being affected by patents held by leading global companies.

Masangbae, CEO of AiBiotics, said on the 31st, “We have developed a POCT ‘Lukine’ that anyone can easily use,” and “We plan to complete performance verification within the year, complete clinical evaluation next year, and launch it around 2026.” He said, “Our long-term goal is to open an ‘era of home diagnostics’ where every home has a diagnostic device, like a coffee machine.”

CEO Ma, who graduated from Hanyang University’s Department of Chemical Engineering, worked as a semiconductor process engineer at Samsung Electronics for over 10 years starting in 1993 before entering the bio-equipment field.

While many domestic diagnostic startups are focusing on developing reagents using specific biomarkers, he focused on equipment development from the beginning. This is because he judged it important to develop domestic equipment and build a hardware platform as Samsung Electronics’ semiconductors experienced their golden age of rising to the top in the world.

After its founding in 2017, the initial version of Lukin was completed around 2020. Since then, it has been working on upgrading the equipment to miniaturize it and reduce errors.

In order to perform molecular diagnostics (PCR) used to detect infectious diseases, etc., a patient sample must be collected at a hospital, etc., sent to a laboratory, and then follow-up work is required. Genetic material is extracted, treated with a reagent, and the temperature is raised and lowered repeatedly using PCR equipment to amplify the genetic material.

From the technology development stage, CEO Ma focused on solving everything from sample preprocessing to result derivation with a single device. POCT should be easy to use in any medical institution, but if it cannot handle the preprocessing process, it is just a ‘half-baked device.’ If a POCT with poor preprocessing technology is introduced, separate personnel are needed to preprocess the sample so that the machine can handle it. The meaning of on-site diagnosis fades.

The key is microfluidics. This is why global POCT leaders such as Sepid, acquired by Danaher for $4.5 billion in 2016, and Genmark, acquired by Roche for $1.8 billion in 2021, have developed their own preprocessing technologies and secured patents.

Representative Ma said, “We have secured a patent for a rotary type that is completely different from the existing commercialized syringe, roller, and piston methods,” and “It has the advantage of being able to expand the usability by integrating all the functions performed in the laboratory into a single cartridge and simply changing the temperature conditions and reagents.”

He receives medical advice from his older brother, Co-CEO Sang-hyeok Ma. Co-CEO Sang-hyeok Ma, who is the head of the pediatrics department at Changwon Fatima Hospital, is a domestic expert in pediatric infectious diseases.

The goal is to commercialize a product that diagnoses tuberculosis by inserting a stool sample into a lukin. Existing POCT tests for tuberculosis using sputum samples. 30% of the population, including children and the elderly, cannot spit out sputum, making POCT testing impossible.

Professor Kim Myeong-ok of Kyungsang University is also developing a product for early diagnosis of dementia using a biomarker. It is being promoted as a pertussis diagnosis project. CEO Ma predicted that it could also be supplied as an environmental monitoring product to food companies with increasing demand for microbiological testing.

– Translated to Google –

Reporter Lee Ji-hyun bluesky@hankyung.com

「주식회사 에이아이바이오틱스 주주 귀하」

제7기 정기주주총회 소집통지서

주주님의 건승과 댁내의 평안을 기원합니다.

당사는 상법 제 363조와 정관 제23조에 의거 제7기 정기주주총회를 다음과 같이 소집하오니 참석하여 주시기 바랍니다.

——————————————- 다          음 ——————————————-

1. 일   시 : 2024년 3월 28일(목), 오전 11시

2. 장   소 : 경기도 수원시 영통구 신원로 88, 101동 606호(디지털엠파이어2)

(주)에이아이바이오틱스 회의실

3. 회의의 내용 및 안건사항

<안건사항>

– 제1호 의안 : 제7기 재무상태표, 손익계산서 및 결손금처분계산서(안) 승인의 건

– 제2호 의안 : 이사 보수한도 승인의 건

4. 첨부

• [별첨1] 참석장
• 위임장이 필요하신 분은 회사로 연락 주시기 바랍니다. (070-7703-0380)

2024년 03월 14일

주 식 회 사 에 이 아 이 바 이 오 틱 스

대 표 이 사  마 상 배, 마 상 혁  직인생략

AiBiotics (CEO Sang-Bae Ma and Sang-Hyeok Ma) announced that it has established a bridgehead for full-scale global market entry for its flagship product, the all-in-one RT-PCR product for field diagnosis, by participating in the integrated Korean pavilion at Eureka Park, CES 2024, held in Las Vegas, USA. AiBiotics’ participation in this exhibition was made possible through the CES 2024 participation support project of the Changwon Industrial Promotion Agency.

AiBiotics, selected as the first company of the Changwon Special City (Mayor Hong Nam-pyo) Venture Fund in 2020, has continued its efforts for corporate and regional development through government and local government projects such as the Ministry of SMEs and Startups’ TIPS and Startup Leap Package Support Project, and based on this, has developed a product that can diagnose infectious diseases and diseases in real time on site.

AiBiotics expressed its expectations, saying, “Once the all-in-one PCR product is fully launched in the market, it will not only allow us to respond more effectively to the upcoming pandemic, but it will also be of great help in diagnosing and responding to diseases such as tuberculosis and mosquito-borne diseases that are receiving the most attention from international organizations such as the UN and WHO.”

In addition, “This prototype was developed by actively reflecting the needs of the global market through participation in the ‘2023 Arab Health’ exhibition, and we were able to confirm the high interest of companies, universities, and research institutes from the US, Japan, and France who visited AiBiotics’ booth at CES 2024. In particular, we received positive responses to the unique concept that can quickly perform DNA/RNA extraction and PCR processes in a single device, and many responded that they were looking forward to the product launch,” he said.

Having confirmed the possibility of entering the global market in this way, AiBiotics plans to smoothly prepare for entering the American market, establishing a collaboration model with major international organizations, and preparing for mass production.

We are currently pursuing ISO 9001, 14001 certifications, and plan to obtain KC certification within the first half of the year, and ISO13485 and GMP in the second half. We also plan to establish a clinical plan as soon as possible, and to this end, we are currently in discussions with major organizations such as the Korea Disease Control and Prevention Agency, and are also consistently conducting consulting necessary for clinical trials.

We also signed an MOU with M3 Global LLC, a local consulting firm specializing in business entry into the US market, to explore the possibility of entering the US market and to develop business and expand globally.

We plan to pursue ODA projects together with Gyeongsangnam-do and Changwon Special City to apply for cooperation projects with major international organizations, and to this end, we plan to actively discuss with local government officials.

Meanwhile, the world’s largest IT exhibition ‘CES’ hosted by the Consumer Technology Association (CTA) is an exhibition where you can see the flow of innovative technology from all over the world at a glance, and is held every January in Las Vegas, USA. AVING News, which has covered CES for 18 consecutive years, has reported CES news worldwide every year since 2006, and has been conducting ‘BEST OF CES’ and ‘BEST OF MADE IN KOREA’ that select the best innovative products, companies, and technologies. In addition, ‘AVING LIVE’ vividly reports on the issues at the CES site.

기사 원본 : https://kr.aving.net/news/articleView.html?idxno=1787414

The theory that the mother’s uterus is a sterile room is a very dominant and well-known theory. However, there is also an argument that there is no completely sterile room anywhere on Earth. In fact, various microorganisms have been confirmed in amniotic fluid and meconium.

At first, I doubted if there was a problem with the experiment, but as it was repeated, the accumulated data increasingly told me that there are bacteria in the intestines from birth. However, I don’t know if those bacteria are alive. (There are bacteria even near volcanic craters… so do you think there aren’t any there?)
It was a very small amount, but it was definitely there. Even though the Big Bang is said to be the beginning of the beginning from nothing, seeds must have existed there, and it seems that those seeds are in the human intestines.

The rate of bacterial growth is about 15 to 20 minutes. If conditions are perfect, one bacterium can grow to tens of trillions (10^21) in a day. However, in reality, the growth rate and the rate of disappearance or discharge are balanced, and tens of trillions of bacteria exist.

For a very long time, humans and bacteria have been domesticated and harmonized with each other. They live attached to the intestinal wall, are excreted through feces, or are balanced in the skin and various organs.
In any ecosystem, excessive interference upsets the balance, and the broken balance is not good for health. We are interested in understanding that order.

It is important to analyze the genetic properties of bacteria by analyzing DNA in great detail, but we are doing our job to measure the overall harmony and relationship as if looking at a large forest to create the most appropriate environment for each individual. In
order to recognize the human body as a very complex biochemical factory and measure more diverse output values ​​for various variable inputs, a lot of reference data and computing power are needed. Valid input data is very important.
We are trying to find out which bacteria are prevalent before diabetes occurs and what it is like before colon cancer occurs. We are trying to analyze the various things that bacteria in the human body do by entering more diverse parameters.

I want to know what kind of forest it becomes when a river flows through it and it becomes a swamp, and what kind of forest it becomes when the water dries up. If
I know more precisely what causes disruption of order, I think I can prevent it.

Even if it’s not for such a grand purpose, aren’t you curious about what kind of bacteria are inside your body?

#Intestinal microorganisms #Intestinal ecosystem #Uterus #Sterile room #Bacteria #Symbiosis #Diabetes #Colorectal cancer #Smile empathy #AiBiotics

In the semiconductor process, if there is a problem with the wafer, the process chamber is checked for contamination, the process is stopped, and then restored to a high vacuum state.
If the vacuum does not show a problem, it is connected to the RGA equipment that analyzes the residual gas, and a very small amount of residual gas is detected, amplified, and displayed.
If a very small amount of gas peak different from the usual amount is seen compared to the process gas, this is assumed to be the cause of the problem, and the chamber is opened to find the cause.

The above solution works on two principles.
Amplification, a method of amplifying very small signals, amplifies the entire signal and applies the log function. Then, you can see large and small signals at the same time. It is a method of expressing one/ten/hundred/ten million as 1/2/3/4/5. That is the log that many dropouts complain about in high school. It is all useful.
SPC, not the SPC that makes bread, but ‘statistical process control’. The impurities that I saw at first did not have specs in the first place. However, since they were not there normally and are different from ‘normal’, there is a high probability that they will be the cause of the problem. This quality control technique developed in Japan is simple, but surprisingly useful.
(If Manager Kim, who was always sloppy, suddenly starts putting on makeup and buying clothes, statistically speaking, he has someone he likes. It is not necessarily true, but it means that there is a high probability that it will happen.)

When I first received the NGS data analyzing the intestinal microbiota, I tried to analyze it by creating various graphs using existing bio analysis tools, but I couldn’t figure out what was what.

So at AiBiotics, we tried to apply the method used in semiconductor processing.

Chamber is ‘intestine’ and various gases are ‘microbiome’.
We took the log function of intestinal microorganisms, which number hundreds of millions per gram, and expressed them as a graph, even for bacteria that are detected in very small amounts by attaching to the intestinal wall. And as the data accumulated little by little, we began to see special bacteria that patients had that were different from ‘normal’ ones.

There are no specs, but it is clear that they are ‘different’.
Babies born by cesarean section have a significantly higher level of Citrobacter, patients with enteritis have a higher level of Clostridium, and babies who took antibiotics have a higher level of Enterobacter. People with diabetes
have a higher level of Prevotella Corpori, and babies with atopy have a random abnormal pattern of various strains of Firmicutes and Proteo.

A baby with very low diversity but a high concentration of lactic acid bacteria means that the mother is feeding her expensive lactic acid bacteria even though she is feeding her food that is not very diverse. Even though my son’s favorite food is kimchi stew, if there is no Prevotella and only a lot of Vulgatus, it means that he does not eat kimchi and only eats pork.
An uncle who eats ordinary food but has a lot of Acamanthia is a mountaineering fanatic.

If you input the analysis of the abnormal pattern seen in RGA, various analyses are possible like this. However, since there is no specification, it is not possible to make a diagnosis under medical law.
However, various meaningful analyses are possible.

As we accumulated over 2,000 data points, we began to resemble fortune tellers.

Someday, Spec will be created.
Since the pre-meal blood sugar level is set as Spec and diabetes can be diagnosed based on the number, it is necessary to collect gut microbiome data from many patients to create meaningful data.

RGA, introduced 25 years ago by an ambitious semiconductor engineer, has now become a fundamental tool in semiconductor manufacturing.
We are confident that our tool for analyzing gut microbiota will also become a fundamental tool for gut inspection.

#intestinal microorganisms #semiconductor #RGA #log #log function #spores #SPC #statistical process control #NGS #microbiome #citrobacter #clostridium #enterobacter #prevotella #firmicutis #proteo #acamanthia #bulgatus #smile empathy #AiBiotics

It is made with Korean beef of good bloodline, good wheat flour from the American South, tomato paste made from Mediterranean coastal tomatoes, fresh tomatoes grown in Uiryeong, Gyeongnam, lettuce, eggs, cooking oil, vinegar, and mayonnaise mixed with the right amount of salt.
It has a little too much sugar, and slightly old cooking oil was used, and there are some parts that are slightly burnt, but it actually tastes good. Except for the fact that a little bit of fat was added for the taste, there is nothing bad about it.

The person holding me took a big bite. There was so much saliva. It was so wet that it rushed into my esophagus. Most of the saliva is water, but there are various electrolytes, enzymes, and various peptides in the mouth. The amylase, which is abundant in saliva, started to dissolve the starch in the bread. People who don’t brush their teeth often also have various bacteria. Prevotella does more harm in the mouth than in the intestines, and these guys that eat away at the periodontal disease mix with food and enter the stomach.
With each bite, a part of my body goes down my throat. Only a little seasoning and half a piece of lettuce escape, and I give up and go down my throat and into my stomach.

Because of the cola that followed, we crashed to the bottom of our stomach. There was nothing much in the stomach, which was wider than we thought. We passed through without chewing, and the round shape was still there, but something (hydrochloric acid) from the stomach wall started to attack the meat patty.
Gastric acid is a liquid secreted from the stomach to help digestion, and has a pH of 1.5~3.5, and is composed of 0.5% hydrochloric acid and a large amount of potassium chloride and sodium chloride, and plays a major role in protein digestion.

I, who was completely bruised, was crushed into a shapeless porridge and passed through the duodenum into the small intestine. In the small intestine, the shapeless hamburger met the digestive juices and the bread was completely broken down into glucose, the meat into amino acids, and the fat into fatty acids.

The remaining fiber in the lettuce becomes a companion as it passes through the small intestine. I haven’t seen many bacterial friends yet. The bacteria that were supposed to be in abundance in the intestines have not yet appeared. It
is said that the bacteria had a hard time surviving because of the acidic solutions encountered along the way, and they are all on their way to the large intestine.

At some point, bacteria appear, and the acidic solution that has lost its power becomes a world where bacteria can live. Some brave bacteria eat the remaining bile acids and create secondary bile acids to help with metabolic activities.

As time goes by, bacteria become more diverse and numerous, and they settle densely on the walls of the large intestine. The bacteria that settle on the intestinal mucosa rush to their favorite foods and fill their stomachs like crazy.

Bacteroides fracilli, which loves refined flour, protein and trans fats, and oil-loving Ruminococcus were thrilled.

Prebeus, who enjoyed eating seaweed soup, has died out, and the starch-loving Furagilis and the meat-loving Vulgatus are proliferating freely. And thanks to these two bad guys, people are feeling unwell.

The kind-hearted Preveus and Bifidus are hiding in the barrier, starving today but looking forward to tomorrow. And Privotella, who was barely surviving, met a different fate because of this person who took antibiotics for periodontitis, and in their place, the gangster-like Puzo and Enterobacter took their place.

If you eat this kind of food every day, you never know when Proteo, the biggest gangster in this neighborhood, will show up. He’s always looking for barriers and hurting you.

Feeling sorry for only eating a hamburger, he takes a sip of yogurt.
The lactic acid bacteria that pass through the intestines with the food cannot find a place to sit and just pass by. The lactobacilli that were lucky enough to find a place also have a hard time.

A lot of gut bacteria eat the leftover hamburger scraps and spit them out again. There are also dead bacteria all around, and their excrement smells sour. It is quite different from the vicious hydrochloric acid we encountered in our stomach. The bad bacteria that were doing well are not able to fight off the sour smelling SCFA (Short Chain Fat Acid).

Before I knew it… I had become poop.

#poop #junkfood #hamburger #preveus #flagillis #bulgatus #bacteroides #ruminocos #bifidus #prevotella #pujos #enterobacter #proteo #lactobacillus #SCFA #shortchainfattyacids #MisoGonggam #aibiotics

When analyzing the microbiome, we compare the intestinal microorganisms of those who ate various types of probiotics and those who did not, and analyze the results of comparative clinical trials on probiotics and prebiotics.
What we feel here is that probiotics are seeds, and the base fertilizer and fertilizer are food and prebiotics.

1) Obesity group that consumed only lactic acid bacteria
2) Group that consumed fake lactic acid bacteria as a placebo
As a result of comparing the two groups, surprisingly, we were able to confirm a more significant change in intestinal microflora in the group that consumed the fake lactic acid bacteria than in the group that consumed only lactic acid bacteria.
In addition, when only milk was continuously consumed for 4 weeks, the concentration of bifidobacteria increased.

Those who eat good food and exercise regularly are naturally growing lactic acid bacteria. In thousands of intestinal microbiome analyses, I have rarely seen a Korean without lactic acid bacteria in their intestines. LGG lactic acid bacteria and bifidus are found in yogurt sold at the market, salad dressings often seen at buffets, and here and there. One way or another, basic lactic acid bacteria seeds enter the intestines without one’s knowledge. Even kimchi contains lactic acid bacteria.

If you really want to take care of your intestines, you need to supplement good bacteria that are difficult to get from food, and eat good food with prebiotics as fertilizer to help the bacteria grow well.
Each of the 19 types of lactic acid bacteria that you can eat has its own specialty.

Some experts say that you need to eat a lot of probiotics, but good seeds will multiply well if the environment is good even if you don’t put in a lot. Instead, you need to eat good probiotic strains that are equivalent to high-quality flower seeds, not cheap weed seeds, and prebiotics that become compost.

When the intestinal barrier is weak, lactobacilli can sometimes be toxic.
Several years ago, there was a case of sepsis caused by lactobacilli in a woman in her 50s with a severely damaged intestinal barrier.

If less than 10 types of lactic acid bacteria out of thousands of types of intestinal microorganisms take over the intestines, it can actually harm your health. If you were to compare an intestine full of only lactic acid bacteria to an intestine where lactic acid bacteria and symbiotic bacteria live together, you could compare it to a bean sprout pot and a bean tree. A
bean tree that takes root in the soil grows lush leaves and grows abundantly enough to produce offspring, but a bean sprout that grows only by feeding on water from its seeds ends up with a single, bare root without a single leaf.

Lactobacillus is a good seed that strengthens the intestines, but too much of anything is bad, and balance is the only secret to health.

So, we created a balanced probiotic.

#CustomizedLactobacillus #OatLactobacillus #SmileEmpathy #Ive #AIbiotics #Probiotics #Prebiotics #Microbiome #IntestinalMicroorganisms #Lactobacillus #MisoGonggam

The components of farts include air (oxygen/nitrogen) that comes in with food when you eat it, carbon dioxide (CO2) that you breathe in, sulfur dioxide and ammonia that you breathe in through the chemical reaction between digestive fluids and food, and various aromatic gaseous compounds (skatole, indole). And most importantly, various gases (hydrogen, methane) that your intestinal microorganisms produce when they eat food waste are added.

The technology to biochemically produce hydrogen and methane gas has already secured dozens of bacteria and is in the process of commercialization. Hydrogen is produced by bacteria in the intestines of many people, such as Clostridium, Enterobacter, and Klebsiella. In addition, there are more than dozens of bacteria that produce methane gas, and the methane gas emitted by cows is so enormous that it threatens the Earth’s ozone layer.

If your stomach is full of hydrogen and methane gas, it is like a time bomb, so it is better to not hold in your farts as much as possible for your health.

The components that create the smell of fart are mainly aromatic gases called skitol and indole. First, if you look at the molecular formula of skitol, you can see that it has two benzene rings with a methyl group attached to them. If you remove this and attach an amino group, it becomes a perfume that produces a grape-scented scent(!). Also, indole, which creates the savory smell of fart, has a molecular structure similar to strawberry or rose scent and is even used as an ingredient in some perfumes. It is said that
sperm whale feces is also an important perfume ingredient, so farts and perfume may be just a little different.

The difference between the smell of poop and the smell of farts is that poop contains various acids and has a sour smell.
And if the ratio of air is high, you poop often but the smell is not toxic, but if the ratio of air is low and the ratio of meat intake is high, the ratio of ammonia production increases and the smell becomes very toxic. In particular, hydrogen sulfide is a toxic gas and is a toxic gas that caused suffocation and death in old-fashioned toilets and septic tanks.

Men who eat quickly inhale relatively more air, so most of their farts contain more air. They also have shorter bowel movements, so they smell less.
On the other hand, women who like meat inhale less air, so their farts are more pure, so they smell more. If the food they ate yesterday was rich in protein, such as cheese and steak, it’s even worse…
So was the culprit in the elevator earlier him or her?

Most Koreans are a very polite people who don’t make a big fuss about this situation. They know about it but pretend not to know and go to their offices. They may even have a good laugh about farting during morning meetings. Is it a beneficial function of farting?

#Fart #Fart smell #Elevator #Terror #Skitoll #Indol #Perfume #One step difference #Intestinal microbes #Smile empathy #Aibiotics

The idea that poison can be medicine is not just an imagination, and in many cases, poison is used as a treatment.
Exposure to the venom of the funnel-web spider in the rainforests of southern Queensland can cause rapid heartbeat, difficulty breathing, and even death, but the peptide contained in this venom can also prevent the spread of melanoma.
Venom components found in various animals are also being studied as potential therapeutic agents for various diseases. Some conotoxins have a nerve-paralyzing poison called conotoxin, and the painkiller ziconitide, approved by the US Food and Drug Administration in 2004, is one of these conotoxins and is a peptide made of 25 amino acids. This ziconitide is said to be effective in relieving severe pain that does not respond to morphine painkillers.
Technology is gradually developing to purify only the beneficial components from the venom of various animals and use them as medicine.

We have moved from the era of using animal poisons to the era of the microbiome, and now we have entered the era of using bacterial poisons.
The most representative example is the ‘Botox’ injection.
Botulinum toxin is a biological toxic protein extracted from Clostridium botulinum.
The bacteria itself is very common and has no toxicity of its own, but it germinates in anaerobic conditions without oxygen and secretes toxins outside the body. The toxin ‘Botox’ produced by this bacteria, which mainly lives in fish, is one of the most toxic substances among all toxins discovered or developed by mankind to date. The
mass required for Botox to kill an adult male is only 0.5ng/kg. The lethal dose of cyanide, which can kill by simply wiping your nose or mouth with a powdered hand, is 0.15g, the tetrodotoxin, a poison of pufferfish, is 300-500ug, and polonium, known as an ingredient in radioactive black tea, is approximately 10ug, so it is impossible to even guess how strong botulinum toxin is. Just 1ml could kill thousands of people, and just 0.4kg could theoretically poison the entire human race.

Surprisingly, medicine uses the toxicity of this botox for cosmetic purposes. Although it is said that it uses a relatively weak toxin, type A toxin, it must be handled with great care because it is a deadly poison itself. The toxicity of botox is used to improve external appearance by locally paralyzing the muscles of a specific area, or to treat various diseases caused by hypertrophied muscles.
Some people foolishly inject botox into their lips, which have many microvessels, to make their lips plump. This is a dangerous act that can lead to death.

Many companies and research institutes are studying various microbiomes and looking for new drugs like the case of Botox. It’s like finding treasure in a garbage dump…
After various attempts and trial and error, another groundbreaking drug can be found from the secretion of microorganisms.
AI Biotics is also looking for this. Thousands of clinical data and gut microbiome analysis data are still insufficient to find definitive evidence, but as more data accumulates, the identity of the trap set in advance will be revealed.

#spiderman #spider #botox #cyanide #tetrodotoxin #radioactivetea #botulinum #toxicprotein #intestinalmicrobes #smileempathy #Aibiotics